Mendelian Randomisation: A Minireview
نویسنده
چکیده
, © Wells This article is distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and redistribution in any medium, provided that the original author and source are credited. Mendelian randomisation is a technique which, fuelled by the results of GWA studies, can be used to determine causal relationships between intermediate phenotypes such as metabolite levels and outcomes such as cardiovascular disease (Evans and Davey Smith 2015). Much faster and cheaper than randomised controlled trials, and relatively free from the biases of observational studies, it has the potential to identify new drug targets and reduce attrition rates in the pharmaceutical development pipeline.
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Use of Mendelian randomisation to assess potential benefit of clinical intervention.
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